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Bacillus coagulans, is a gram positive spore forming bacterium. It is non-pathogenic and safe for human consumption. It is widely used, well documented, safe and stable Probiotic that promotes gastrointestinal health. Being naturally encapsulated, it is a very tough and stable probiotic making it the probiotic of choice in the food and pharmaceutical industry.

The property of spore formation by Bacillus coagulans is the main characteristic that makes it probiotic of choice in food industry, clinical applications and various applications.

It can survive changing microecological conditions better. Spores can tide unfavourable conditions and germinate when favourable conditions arise. On oral administration, these spores survive the acidic gastric environment and are activated due to the low pH, mechanical churning action of the stomach and water in the gastric environment.

The spore coats imbibe water, swell and the increased water content causes a rise in the metabolic rate of the sporulated bacilli. Outgrowths begin to protrude from the spore-coats. The spores pass on the duodenum where the outgrown cells germinate and transform into viable vegetative cells.

They begin to proliferate in the small intestine, multiplying rapidly. Usually, germination takes place about four hours after ingestion. A large supply of viable Bacillus coagulans is thereby ensured in the small intestine.

These cells settle in the intestinal tract and continue their metabolic activities, producing lactic acid and probably bacteriocins which render the intestinal environment non-conducive for the growth of harmful pathogenic bacteria. The maintenance of a low, constant level of lactic acid on the inner surface of the intestinal tract helps to restore the microecological balance after antibiotic therapy.

Antibiotics therapy may kill beneficial microbes, which help in the synthesis of B-vitamins and digestive enzymes.Since Bacillus coagulans produces only L(+) – lactic acid it does not cause metabolic acidosis.

The spores of Bacillus coagulans are resistant to heat and other adverse environmental conditions, surviving even under a temperature of 100 ℃ for twenty minutes. The spores are two to eight times more resistant to antibiotics than the vegetative cells.

Physical Features

Gram positive, catalase positive, spore forming Bacillus sps.
High Acid and bile tolerance
High thermal stability
Lactic acid producing capacity
Good dispersion

Special Features

Can Survive in harsh environment of stomach acid and bile juices to reach intestine where it colonizes.
Provides immunity and fights against pathogens.
Stable at room temperature. Does not require cold chain
Shelf stable for 3 years
Due to stability at high temperatures, it has wide application in the food industry.

Benefits

Plays a predominant role in intestinal digestion by synthesizing B Vitamins, folic acid, biotin, Vit C, bacteriocins and digestive enzymes such as amylase, protease and lipase.
Helps in assimilation of proteins, digestion of diary products
Plays an important role in the cholesterol metabolism of their host.
Used for Lactose intolerance
Reduces cholesterol levels
Enhances immune status
Effective in vaginitis
Auto-toxication
Supportive therapy for Urticaria, Eczema, Stophulus infantum
It is effective in reducing abdominal cramps and diarrhoea, along with reducing the return of infection.

Applications

Food Industry:

Bacillus coagulans is used as a food supplement / dietary supplement
Bacillus coagulans being in its naturally encapsulated spore form is highly stable and is resistant to high temperatures, most chemicals and physical conditions during manufacturing processes of food products. So it is an ideal ingredient which can be added to foods, beverages and supplements to fortify them.
Confectionery – Candies, Gummies, Chocolates, Cereal bars
Baking products – Cakes, Muffins, Cookies, Biscuits, Pizzas
Diary products – Cheese, milk products, Ice cream, Yoghurt
Beverages – Coffee, Tea, Juices
Sports beverages
Protein bars
Functional foods

Pharma Industry

Bacillus coagulans used in combination with antibiotics and Vitamins in Pharmaceutical industry

Animal Healthcare

Bacillus coagulans, which has high temperature resistance, acid resistance, bile resistance makes it best suitable for use as feed additive in Poultry, Cattle feed, Pet food, horses etc.

Promotes Nutrient metabolism
Regulates Immune function
Possesses Antioxidant ability and alleviates the toxicity of heavy metals

Specifications

S.No.	Test	Specification
01.	Description	Free flowing Beige to light brown coloured powder with characteristic odour
02.	Identification	Gram-positive rods with terminal spores.
03.	Lactic Acid Producing Capacity	Not less than 12 ml of 0.05 N Sodium hydroxide should be consumed.
04.	Loss on Drying	Not more than 3% w/w.
05.	Viable Spores Count	6 / 15 / 25/ 50 / 100 / 150 / 200 / 250 Billion Spores per Gram
06.	Pathogens 1. E.coli 2. Salmonella sps. 3. Pseudononas aeruginosa 4. Staphylococcus aureus	Should be absent/10 gms
07.	Yeast &Mould count	< 50 Cfu per Gram
08.	Other Organisms	1000 to 0.01 Million Cfu per Gram
09.	Bacillus cereus count	< 100 cfu/gm
10.	Heavy metals a. Lead b. Cadmium c. Arsenic d. Mercury	NMT 3 ppm NMT 1 ppm NMT 1 ppm NMT 0.1 ppm

BACILLUS COAGULANS ABBC-7 (MTCC 25397)

Physical Features

Special Features

Benefits

Applications

Specifications